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|a Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity |h [electronic resource]. |
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|a Bethesda, MD : |b The American Society for Clinical Investigation, Inc., |c 2011. |
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|a pages 683-694 : |b illustrations (some color). |
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|a Published IN: Journal of clinical investigation. Volume 121, no. 2 (2011 February). |
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|a Type 1 or invariant NKT (iNKT) cell agonists, epitomized by α-galactosylceramide, protect against cancer largely by IFNγ–dependent mechanisms. Here we describe what we believe to be a novel IFN-γ–independent mechanism induced by -mannosylceramide, which also defines a potentially new class of iNKT cell agonist, with an unusual β-linked sugar. Like -galactosylceramide, β-mannosylceramide directly activates iNKT cells from both mice and humans. In contrast to α-galactosylceramide, protection by β-mannosylceramide was completely dependent on NOS and TNF-α, neither of which was required to achieve protection with α-galactosylceramide. Moreover, at doses too low for either alone to protect, β-mannosylceramide synergized with α-galactosylceramide to protect mice against tumors. These results suggest that treatment with β-mannosylceramide provides a distinct mechanism of tumor protection that may allow efficacy where other agonists have failed. Furthermore, the ability of β-mannosylceramide to synergize with α-galactosylceramide suggests treatment with this class of iNKT agonist may provide protection against tumors in humans |
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|a Electronic reproduction. |c University of the Virgin Islands, |d 2016. |f (UVI Digital Library) |n Mode of access: World Wide Web. |n System requirements: Internet connectivity; Web browser software. |
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|a University of the Virgin Islands. |
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|a Cells -- Immunology -- Research. |
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|a Castillo, Bernard F., II. |
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|a UVI |c Faculty Publications |
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|u https://uvi.sobeklibrary.com/AA00000023/00001 |y Click here for full text |
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|a https:/uvi.sobeklibrary.com/content/AA/00/00/00/23/00001/JCI42314thm.jpg |
